Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO)
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چکیده
منابع مشابه
Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO)
BACKGROUND Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, non-infectious osteopathy that affects predominantly patients </= 18 years of age. There is no uniformly effective treatment. Our objective is to describe clinical, magnetic resonance imaging (MRI), and bone resorption response to intravenous pamidronate in pediatric CRMO. METHODS We report our prospectively docu...
متن کاملChronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare aseptic, auto-inflammatory bone disorder. CRMO presents with bone pain with or without fever. The diagnosis of CRMO is a diagnosis of exclusion and should be included in the differential diagnosis of chronic inflammatory bone lesions in children. Cultures of the bone are typically sterile, antibiotic therapy does not result in clinic...
متن کاملHeight and weight development following cyclical intravenous pamidronate in children and adolescents with chronic recurrent multifocal osteomyelitis (CRMO)
Methods 10 patients (5 M, 5 F) were enrolled, with mean (range) age 11.4 (4.5–16.3) years at IVP treatment. All patients received a 3-day infusion of IVP (0.5 mg/kg/day for the first dose; 1 mg/kg/day subsequently), followed by 1-day infusion monthly or 3-day infusion every 3 months until resolution of MRI documented bone inflammation. Weight and height were measured prior to first IVP, at 1yea...
متن کاملChronic Recurrent Multifocal Osteomyelitis (CRMO): four cases treated with aminobisphosphonate (pamidronate)
CRMO is an autoinflammatory disease of children and young adults, characterized by the insidious onset of local pain and swelling in affected bone and fever. The bone lesions are radiologically characterized as multiple luciens surrounded by defined zones of patchy but dense sclerosis, cortical tickening from periosteal new bone formation, and increased bone size with different bones involved. ...
متن کاملBone scintigraphy in diagnosing chronic recurrent multifocal osteomyelitis
A 10-year-old boy was referred to us for evaluation of FUO accompanied with bone pain in both calves. Three hours after intravenous injection of 13 mCi of 99mTc-MDP, whole body scan in multiple spot views was performed. The scan showed symmetrical areas of diffusely increased tracer uptake in multiple long bones. Histopathologic evaluation confirmed osteosclrosis and fibrotic changes...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2009
ISSN: 1546-0096
DOI: 10.1186/1546-0096-7-2